PRENATAL SCHIZENCEPHALY DIAGNOSIS WITH PROGRESSIVE UNILATERAL TO BILATERAL EVOLUTION

CASE REPORT

Abstract

Schizencephaly is a rare congenital malformation of the central nervous system (CNS). Belonging to the group of CNS cell migration defects, it appears between the 2nd and 5th month of gestation, characterized by a gray dysmorphic substance outlining the slits in the cerebral cortex that extend medially from the subarachnoid space communicating with the ipsilateral cerebral ventricle. This report is from a fetus that was referred with the diagnosis of ventriculomegaly and a morphological examination identified a rare pathology of the CNS, unilateral type II schizencephaly. During monitoring it evolved to a bilateral form with progressive increase in the cleft, subarachnoid space, cerebral ventricle and identification of associated brain abnormalities. This evolution from unilateral to bilateral form is not described in the medical literature. You can assume that the diagnosis was very early and although the event had been bilateral, its manifestation took some time to become identified on ultrasound examination. An etiology, associated anomalies, differential diagnosis and prognostics factors in schizencephaly will be addressed.